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Some of the programs support USB installs, what ones will and won't work this way? I ask before I try because I like to not have to uninstall to do default install should it not work.
The Keep is the only one that has specific support for portable installations. In portable mode, its databases and application settings are all self contained within its application folder.
FM8 and AS3 are fairly self contained and will run from a removable drive, but they do store their application settings in the system registry.